p16 gene การใช้

Rather than p16 gene mutations being frequent, they appeared to be rare.
Increased expression of the p16 gene as organisms age reduces the proliferation of stem cells.
He added that part of the problem might be that newly isolated tumors also contained healthy cells, and the presence of healthy cells in the assays might make it appear that there were fewer mutated p16 genes.
In an earlier study, when he was with the National Center for Human Genome Research in Bethesda, Md ., Dracopoli found that half of all melanoma-prone families showed defects in the p16 gene that appeared to be related to the disease.
So when Dr . Mark H . Skolnick and Dr . Alexander Kamb, both of the University of Utah Medical Center in Salt Lake City and Myriad Genetics Inc . of Salt Lake City, reported that more than half of the tumor cells they had examined had a mutated p16 gene, and that these cancers included some of the most common and most deadly human tumors, molecular biologists and cancer specialists hailed the finding.